Regular exercise improves cardiovascular health, lowers insulin resistance, and aids in weight management.1 However, if you use a continuous glucose monitor (CGM), you may notice spikes in your blood sugar levels after physical activity. This can be frustrating because you are taking steps to improve your health that seem to be backfiring. However, it is important to keep in mind that glucose spikes after exercise do not usually lead to weight gain as glucose released into the bloodstream with exercise is typically used by muscles or converted to glycogen.
When exercise intensity increases, the stress hormones, cortisol and adrenaline, are released. These hormones cause blood glucose to increase. This response ensures that body cells have enough energy. As cortisol increases blood glucose to meet the increased demand for energy, insulin shuttles it from the bloodstream into muscle cells.2
If you are not insulin resistant and exercise at a low to moderate level, glucose will be moved into muscle cells at about the same rate it is produced.3Your exercise intensity will determine how much cortisol and adrenaline are released and how quickly glucose can be moved into your muscle cells. Intense exercise, an inability to produce insulin, and insulin resistance, can all cause blood glucose increases during and after exercise.
Metabolism varies by individual; each person has different metabolic responses to different types of exercise, but there are some trends. Your CGM can help you determine which types of exercise will best help you meet your goal if it is to minimize blood sugar spikes after exercise.
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How Does Exercise Affect Your Blood Sugar?
Exercise has two effects on blood glucose:
- It lowers blood glucose by making muscle cells more sensitive to insulin.
- Moderate to intense exercise can cause short-lived glucose spikes.
Exercise Increases Insulin Sensitivity
The type and intensity of exercise determine the effect of exercise on blood sugar. Moderate to intense levels of exercise can lower blood sugar for up to 24 hours, according to the American Diabetes Association.10 This is because muscle cells are more sensitive to insulin after more intense exercise.
Muscle cells have two ways of transporting GLUT 4 receptors to cell membranes so glucose can enter muscle cells, insulin and exercise. Exercise allows glucose to enter muscle cells in a way that is not insulin-dependent.11 At rest and after eating, insulin moves glucose into muscle cells to restore muscle glycogen stores. Storing glycogen in muscle cells provides them with a ready source of glucose for energy.12
High-intensity interval training (HIIT): HIIT alternates short bursts of higher and lower intensity exercise, resulting in greater gains in cardiovascular fitness.13
When metabolically healthy people performed HIIT for 7.5 to 20 minutes per week for two weeks and at 80% maximal capacity, it increased insulin sensitivity for three days post-exercise. 14
Resistance exercise: Resistance exercise decreases insulin resistance, increases muscular strength, increases lean muscle mass and bone density, and improves glycemic control.13 After an initial increase in blood glucose, resistance exercise can lower fasting blood glucose for at least 24 hours after exercise.13
Moderate To Intense Level Exercise Can Cause Short-Term Glucose Spikes
The amount by which your blood sugar rises after exercise is determined by the intensity of your workout.
In metabolically healthy people engaged in low to moderate-intensity aerobic exercise, the increase in glucose uptake into skeletal muscle equals the glucose produced in the liver. Blood glucose levels do not change as long as muscle glycogen is not depleted.
Longer or more intense exercise can cause blood glucose to rise faster than it can be used. When moderate-intensity exercise exceeds two hours or when exercise intensity exceeds 60% V02max, adrenalin and cortisol levels increase as do blood sugar levels. 14,15
Brief, intense exercise (VO2max exceeding 80%) stimulates a marked release of cortisol and adrenaline (by 14- to 18-fold), resulting in a 7- to 8-fold increase in glucose production. Blood insulin levels remain the same or increase slightly.10 Blood glucose utilization increases 3- to 4-fold.14
Blood glucose is released faster than it can be taken up by muscle cells. As adrenaline and cortisol levels fall after exercise ends, insulin release increases and glucose is shuttled into the muscle and liver to be stored as glycogen. Blood glucose levels fall. However, elevated blood glucose levels can persist for one to two hours after exercise.10,12
<p class="pro-tip">Exercise lowers blood glucose for 24 hours or more by increasing insulin sensitivity. High-intensity or prolonged exercise can cause a short-term increase in blood glucose.</p>
The Effects of Cortisol, Adrenalin, and Insulin on Blood Glucose (Sugar)
Cortisol, adrenalin, and glucagon increase blood glucose, and insulin lowers it. Which effect predominates depends on exercise intensity and length.
Cortisol
Cortisol, also known as “stress hormone,” rises when your body is subjected to physical, psychological, or environmental stress. Cortisol levels are influenced by hydration status, meal timing, and time of day.7
Excess cortisol can cause:8
- Increased insulin
- Increased blood glucose
- Insulin resistance
Adrenaline
Adrenaline (epinephrine) is released when the body is under stress. It works with cortisol to raise blood glucose. Adrenalin inhibits insulin release (to allow blood glucose levels to increase) and increases glucagon sensitivity in the liver. Glucagon instructs the liver to break down stored glycogen and release glucose into the bloodstream.
Adrenalin output increases when moderate exercise exceeds two hours or during brief bouts of intense exercise.9 Following exercise, adrenaline levels typically return to normal within minutes.
Insulin
Insulin promotes glucose uptake into muscle and fat cells by bringing GLUT 4 receptors to the cell membrane to allow glucose to pass into the cell. Insulin also stimulates the liver to store glucose as glycogen.
<p class="pro-tip">Cortisol, adrenaline, and glucagon raise blood glucose. Insulin counteracts the action of these three hormones by lowering blood glucose and inhibiting glucose production in the liver.</p>
<p class="pro-tip"><strong>Learn about </strong> <a href=what-factors-affect-blood-sugar>factors that can affect your blood sugar (besides exercise)</a>.</p>
How Long Does Blood Sugar Stay Elevated After Exercise?
After moderate to intense exercise, blood glucose can remain high for one to two hours. At the beginning of exercise, insulin levels decrease to allow blood glucose to increase. As a result, there is a marked increase in glucose production (sometimes 7-fold) but only a small increase in glucose utilization (a 4-fold increase before exhaustion).16
<p class="pro-tip">Post-exercise hyperglycemia should resolve within one to two hours after exercise is stopped.</p>
Are Blood Glucose Spikes After Exercise Bad?
Blood glucose spikes after exercise are not necessarily unhealthy since most glucose will be absorbed within one to two hours by muscle cells or converted back to glycogen in the liver.
<p class="pro-tip">Read next: Things you can learn about your body with a CGM</p>
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References
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- Riddell, M.C., Pooni, R., Fontana, F.Y., Scott, S.N. (2020) Diabetes Technology and Exercise. Endocrinology and Metabolism Clinics of North America, 49(1), 109-125. https://doi.org/10.1016/j.ecl.2019.10.011
- Umpierre D, Ribeiro PAB, Kramer CK, et al. Physical Activity Advice Only or Structured Exercise Training and Association With HbA1c Levels in Type 2 Diabetes: A Systematic Review and Meta-analysis. JAMA. 2011;305(17):1790–1799. https://doi.org/10.1001/jama.2011.576
- Hargreaves, M., Spriet, L.L. Skeletal muscle energy metabolism during exercise. Nat Metab 2, 817–828 (2020). https://doi.org/10.1038/s42255-020-0251-4
- Leite, S.A., Monk, A.M., Upham, P.A. et al. Low cardiorespiratory fitness in people at risk for type 2 diabetes: early marker for insulin resistance. Diabetol Metab Syndr 1, 8 (2009). https://doi.org/10.1186/1758-5996-1-8
- Fletcher, G.F., Balady, G.J., Amsterdam, E.A., Chaitman, B., Eckel, R., Fleg, J., Froelicher, V.F., Leon, A.S., Pina, I.L., Rodney, R., Simons-Morton, D.A., Williams, M.A., & Bazzarre, T. (2001) Exercise Standards for Testing and Training. Circulation, 104(14), 1694-1740. https://doi.org/10.1161/hc3901.095960
- Judson, D.A., Maresh, C.M., Yamamoto, L.M., Farrell, M.J., Armstrong, L.E., Kraemer, W.J., Volek, J.S., Spiering, B.A., Casa, D.J., & Anderson, J.M. (2008) Effect of hydration state on resistance exercise-induced endocrine markers of anabolism, catabolism, and metabolism. Journal of Applied Physiology, 105(3),816-824. https://doi.org/10.1152/japplphysiol.01010.2007
- Whitworth, J. A., Williamson, P. M., Mangos, G., & Kelly, J. J. (2005). Cardiovascular consequences of cortisol excess. Vascular health and risk management, 1(4), 291–299. https://doi.org/10.2147/vhrm.2005.1.4.291
- Getting Started Safely: Blood Sugar and Exercise. (n.d.) American Diabetes Association. Retrieved May 12, 2022 from: https://www.diabetes.org/healthy-living/fitness/getting-started-safely/blood-glucose-and-exercise
- Errol B. Marliss, Mladen Vranic; Intense Exercise Has Unique Effects on Both Insulin Release and Its Roles in Glucoregulation: Implications for Diabetes. Diabetes 1 February 2002; 51 (suppl_1): S271–S283. https://doi.org/10.2337/diabetes.51.2007.S271
- Nystrom, F.H., Quon, M.J. (1999) Insulin Signalling: Metabolic Pathways and Mechanisms for Specificity. Cellular Signaling, 11(8), 563-574. https://doi.org/10.1016/S0898-6568(99)00025-X
- Colberg, S. R., Sigal, R. J., Fernhall, B., Regensteiner, J. G., Blissmer, B. J., Rubin, R. R., Chasan-Taber, L., Albright, A. L., Braun, B., American College of Sports Medicine, & American Diabetes Association (2010). Exercise and type 2 diabetes: the American College of Sports Medicine and the American Diabetes Association: joint position statement. Diabetes care, 33(12), e147–e167. https://doi.org/10.2337/dc10-9990
- Sigal RJ, Kenny GP, Boule NG, Wells GA, Prud'homme D, Fortier M, Reid RD, Tulloch H, Coyle D, Phillips P, Jennings A, Jaffey J. Effects of Aerobic Training, Resistance Training, or Both on Glycemic Control in Type 2 Diabetes: A Randomized Trial. Ann Intern Med. 2007; 147: 357-69. https://doi.org/10.7326/0003-4819-147-6-200709180-00005
- Adams O. P. (2013). The impact of brief high-intensity exercise on blood glucose levels. Diabetes, metabolic syndrome and obesity : targets and therapy, 6, 113–122. https://doi.org/10.2147/DMSO.S29222
- Duclos, M., Virally, M., & Dejager, S. (2011) Exercise in the Management of Type 2 Diabetes Mellitus: What are the Benefits and how does it Work? The Physician and Sportsmedicine, 39(2), 98-106. https://doi.org/10.3810/psm.2011.05.1899
- Purdon, C., Brousson, M., Nyveen, S.L., Miles, P.D., Halter, J.B., Vranic, M., & Marliss, E.B. (1993) The roles of insulin and catecholamines in the glucoregulatory response during intense exercise and early recovery in insulin-dependent diabetic and control subjects. The Journal of Clinical Endocrinology & Metabolism, 76(3), 566–573. https://doi.org/10.1210/jcem.76.3.8445012